AustralieFrV1, Main, Exploration, bibRecord, 000776

Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa

Identifieur interne : 000776 ( Main/Exploration ); précédent : 000775; suivant : 000777

Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa

Auteurs : Koen Vandelannoote [Belgique] ; Conor J. Meehan [Belgique] ; Miriam Eddyani [Belgique] ; Dissou Affolabi [Bénin] ; Delphin Mavinga Phanzu ; Sara Eyangoh [Cameroun] ; Kurt Jordaens [Belgique] ; Françoise Portaels [Belgique] ; Kirstie Mangas [Australie] ; Torsten Seemann [Australie] ; Laurent Marsollier [France] ; Estelle Marion [France] ; Annick Chauty [Bénin] ; Jordi Landier [Cameroun, France] ; Arnaud Fontanet [France] ; Herwig Leirs [Belgique] ; Timothy P. Stinear [Australie] ; Bouke C. De Jong [Belgique]

Source :

Genome Biology and Evolution [ 1759-6653 ] ; 2017.

RBID : PMC:5381664

Descripteurs français

KwdFr :
- Afrique, Analyse de séquence d'ADN, Génome bactérien, Génétique des populations, Humains, Mycobacterium ulcerans (génétique), Mycobacterium ulcerans (pathogénicité), Phylogénie, Polymorphisme de nucléotide simple, Ulcère de Buruli (génétique), Ulcère de Buruli (microbiologie), Ulcère de Buruli (transmission), Variation génétique, Évolution moléculaire.
MESH :
- génétique : Mycobacterium ulcerans, Ulcère de Buruli.
- microbiologie : Ulcère de Buruli.
- pathogénicité : Mycobacterium ulcerans.
- transmission : Afrique, Analyse de séquence d'ADN, Génome bactérien, Génétique des populations, Humains, Phylogénie, Polymorphisme de nucléotide simple, Ulcère de Buruli, Variation génétique, Évolution moléculaire.

English descriptors

KwdEn :
- Africa, Buruli Ulcer (genetics), Buruli Ulcer (microbiology), Buruli Ulcer (transmission), Evolution, Molecular, Genetic Variation, Genetics, Population, Genome, Bacterial, Humans, Mycobacterium ulcerans (genetics), Mycobacterium ulcerans (pathogenicity), Phylogeny, Polymorphism, Single Nucleotide, Sequence Analysis, DNA.
MESH :
- genetics : Buruli Ulcer, Mycobacterium ulcerans.
- microbiology : Buruli Ulcer.
- pathogenicity : Mycobacterium ulcerans.
- transmission : Buruli Ulcer.
- Africa, Evolution, Molecular, Genetic Variation, Genetics, Population, Genome, Bacterial, Humans, Phylogeny, Polymorphism, Single Nucleotide, Sequence Analysis, DNA.

Abstract

Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa. The genetic diversity of African M. ulcerans was found to be restricted due to the bacterium’s slow substitution rate coupled with its relatively recent origin. We identified two specific M. ulcerans lineages within the African continent, and inferred that M. ulcerans lineage Mu_A1 existed in Africa for several hundreds of years, unlike lineage Mu_A2, which was introduced much more recently, approximately during the 19th century. Additionally, we observed that specific M. ulcerans epidemic Mu_A1 clones were introduced during the same time period in the three hydrological basins that were well covered in our panel. The estimated time span of the introduction events coincides with the Neo-imperialism period, during which time the European colonial powers divided the African continent among themselves. Using this temporal association, and in the absence of a known BU reservoir or—vector on the continent, we postulate that the so-called "Scramble for Africa" played a significant role in the spread of the disease across the continent.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381664

DOI: 10.1093/gbe/evx003
PubMed: 28137745
PubMed Central: 5381664

Affiliations:

Le document en format XML

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<author><name sortKey="Seemann, Torsten" sort="Seemann, Torsten" uniqKey="Seemann T" first="Torsten" last="Seemann">Torsten Seemann</name>
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<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marsollier, Laurent" sort="Marsollier, Laurent" uniqKey="Marsollier L" first="Laurent" last="Marsollier">Laurent Marsollier</name>
<affiliation wicri:level="3"><nlm:aff id="evx003-aff9">CRCNA Inserm U892 CNRS 6299, CHU & Université d’Angers, Angers, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CRCNA Inserm U892 CNRS 6299, CHU & Université d’Angers, Angers</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Angers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marion, Estelle" sort="Marion, Estelle" uniqKey="Marion E" first="Estelle" last="Marion">Estelle Marion</name>
<affiliation wicri:level="3"><nlm:aff id="evx003-aff9">CRCNA Inserm U892 CNRS 6299, CHU & Université d’Angers, Angers, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CRCNA Inserm U892 CNRS 6299, CHU & Université d’Angers, Angers</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Angers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chauty, Annick" sort="Chauty, Annick" uniqKey="Chauty A" first="Annick" last="Chauty">Annick Chauty</name>
<affiliation wicri:level="1"><nlm:aff id="evx003-aff10">CDTUB de Pobè, Pobè, Benin</nlm:aff>
<country xml:lang="fr">Bénin</country>
<wicri:regionArea>CDTUB de Pobè, Pobè</wicri:regionArea>
<wicri:noRegion>Pobè</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Landier, Jordi" sort="Landier, Jordi" uniqKey="Landier J" first="Jordi" last="Landier">Jordi Landier</name>
<affiliation wicri:level="1"><nlm:aff id="evx003-aff5">Service de Mycobactériologie, Centre Pasteur du Cameroun, Yaoundé, Cameroun</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>Service de Mycobactériologie, Centre Pasteur du Cameroun, Yaoundé</wicri:regionArea>
<wicri:noRegion>Yaoundé</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="evx003-aff11">Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name>
<affiliation wicri:level="3"><nlm:aff id="evx003-aff11">Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leirs, Herwig" sort="Leirs, Herwig" uniqKey="Leirs H" first="Herwig" last="Leirs">Herwig Leirs</name>
<affiliation wicri:level="4"><nlm:aff id="evx003-aff2">Evolutionary Ecology Group University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Evolutionary Ecology Group University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stinear, Timothy P" sort="Stinear, Timothy P" uniqKey="Stinear T" first="Timothy P." last="Stinear">Timothy P. Stinear</name>
<affiliation wicri:level="4"><nlm:aff id="evx003-aff7">Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Jong, Bouke C" sort="De Jong, Bouke C" uniqKey="De Jong B" first="Bouke C." last="De Jong">Bouke C. De Jong</name>
<affiliation wicri:level="1"><nlm:aff id="evx003-aff1">Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Genome Biology and Evolution</title>
<idno type="eISSN">1759-6653</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa</term>
<term>Buruli Ulcer (genetics)</term>
<term>Buruli Ulcer (microbiology)</term>
<term>Buruli Ulcer (transmission)</term>
<term>Evolution, Molecular</term>
<term>Genetic Variation</term>
<term>Genetics, Population</term>
<term>Genome, Bacterial</term>
<term>Humans</term>
<term>Mycobacterium ulcerans (genetics)</term>
<term>Mycobacterium ulcerans (pathogenicity)</term>
<term>Phylogeny</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Afrique</term>
<term>Analyse de séquence d'ADN</term>
<term>Génome bactérien</term>
<term>Génétique des populations</term>
<term>Humains</term>
<term>Mycobacterium ulcerans (génétique)</term>
<term>Mycobacterium ulcerans (pathogénicité)</term>
<term>Phylogénie</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Ulcère de Buruli (génétique)</term>
<term>Ulcère de Buruli (microbiologie)</term>
<term>Ulcère de Buruli (transmission)</term>
<term>Variation génétique</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Buruli Ulcer</term>
<term>Mycobacterium ulcerans</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mycobacterium ulcerans</term>
<term>Ulcère de Buruli</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Ulcère de Buruli</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Buruli Ulcer</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Mycobacterium ulcerans</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Mycobacterium ulcerans</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Buruli Ulcer</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Africa</term>
<term>Evolution, Molecular</term>
<term>Genetic Variation</term>
<term>Genetics, Population</term>
<term>Genome, Bacterial</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Afrique</term>
<term>Analyse de séquence d'ADN</term>
<term>Génome bactérien</term>
<term>Génétique des populations</term>
<term>Humains</term>
<term>Phylogénie</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Ulcère de Buruli</term>
<term>Variation génétique</term>
<term>Évolution moléculaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, <italic>Mycobacterium ulcerans</italic>
, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of <italic>M. ulcerans</italic>
 by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa. The genetic diversity of African <italic>M. ulcerans</italic>
 was found to be restricted due to the bacterium’s slow substitution rate coupled with its relatively recent origin. We identified two specific <italic>M. ulcerans</italic>
 lineages within the African continent, and inferred that <italic>M. ulcerans</italic>
 lineage Mu_A1 existed in Africa for several hundreds of years, unlike lineage Mu_A2, which was introduced much more recently, approximately during the 19th century. Additionally, we observed that specific <italic>M. ulcerans</italic>
 epidemic Mu_A1 clones were introduced during the same time period in the three hydrological basins that were well covered in our panel. The estimated time span of the introduction events coincides with the Neo-imperialism period, during which time the European colonial powers divided the African continent among themselves. Using this temporal association, and in the absence of a known BU reservoir or—vector on the continent, we postulate that the so-called "Scramble for Africa" played a significant role in the spread of the disease across the continent.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ablordey, As" uniqKey="Ablordey A">AS Ablordey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aguiar, J" uniqKey="Aguiar J">J. Aguiar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andersen, Fo" uniqKey="Andersen F">FO. Andersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrews, S" uniqKey="Andrews S">S. Andrews</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baele, G" uniqKey="Baele G">G Baele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrick, Je" uniqKey="Barrick J">JE Barrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bolz, M" uniqKey="Bolz M">M Bolz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouckaert, R" uniqKey="Bouckaert R">R Bouckaert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brosch, R" uniqKey="Brosch R">R Brosch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bruen, Tc" uniqKey="Bruen T">TC Bruen</name>
</author>
<author><name sortKey="Philippe, H" uniqKey="Philippe H">H Philippe</name>
</author>
<author><name sortKey="Bryant, D" uniqKey="Bryant D">D. Bryant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Comas, I" uniqKey="Comas I">I Comas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cook, A" uniqKey="Cook A">A. Cook</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corander, J" uniqKey="Corander J">J Corander</name>
</author>
<author><name sortKey="Marttinen, P" uniqKey="Marttinen P">P Marttinen</name>
</author>
<author><name sortKey="Siren, J" uniqKey="Siren J">J Siren</name>
</author>
<author><name sortKey="Tang, J" uniqKey="Tang J">J. Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corander, J" uniqKey="Corander J">J Corander</name>
</author>
<author><name sortKey="Tang, J" uniqKey="Tang J">J. Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Croucher, Nj" uniqKey="Croucher N">NJ Croucher</name>
</author>
<author><name sortKey="Harris, Sr" uniqKey="Harris S">SR Harris</name>
</author>
<author><name sortKey="Grad, Yh" uniqKey="Grad Y">YH Grad</name>
</author>
<author><name sortKey="Hanage, Wp" uniqKey="Hanage W">WP. Hanage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debacker, M" uniqKey="Debacker M">M Debacker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debacker, M" uniqKey="Debacker M">M Debacker</name>
</author>
<author><name sortKey="Zinsou, C" uniqKey="Zinsou C">C Zinsou</name>
</author>
<author><name sortKey="Aguiar, J" uniqKey="Aguiar J">J Aguiar</name>
</author>
<author><name sortKey="Meyers, Wm" uniqKey="Meyers W">WM Meyers</name>
</author>
<author><name sortKey="Portaels, F" uniqKey="Portaels F">F. Portaels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Demangel, C" uniqKey="Demangel C">C Demangel</name>
</author>
<author><name sortKey="Stinear, Tp" uniqKey="Stinear T">TP Stinear</name>
</author>
<author><name sortKey="Cole, St" uniqKey="Cole S">ST. Cole</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doig, Kd" uniqKey="Doig K">KD Doig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name>
</author>
<author><name sortKey="Ho, Sy" uniqKey="Ho S">SY Ho</name>
</author>
<author><name sortKey="Phillips, Mj" uniqKey="Phillips M">MJ Phillips</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A. Rambaut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name>
</author>
<author><name sortKey="Nicholls, Gk" uniqKey="Nicholls G">GK Nicholls</name>
</author>
<author><name sortKey="Rodrigo, Ag" uniqKey="Rodrigo A">AG Rodrigo</name>
</author>
<author><name sortKey="Solomon, W" uniqKey="Solomon W">W. Solomon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Durnez, L" uniqKey="Durnez L">L Durnez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Durnez, L" uniqKey="Durnez L">L Durnez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eddyani, M" uniqKey="Eddyani M">M Eddyani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eddyani, M" uniqKey="Eddyani M">M Eddyani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garrison, E" uniqKey="Garrison E">E Garrison</name>
</author>
<author><name sortKey="Marth, G" uniqKey="Marth G">G. Marth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="George, Km" uniqKey="George K">KM George</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giles Vernick, T" uniqKey="Giles Vernick T">T Giles-Vernick</name>
</author>
<author><name sortKey="Owona Ntsama, J" uniqKey="Owona Ntsama J">J Owona-Ntsama</name>
</author>
<author><name sortKey="Landier, J" uniqKey="Landier J">J Landier</name>
</author>
<author><name sortKey="Eyangoh, S" uniqKey="Eyangoh S">S. Eyangoh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gryseels, S" uniqKey="Gryseels S">S Gryseels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harrison, P" uniqKey="Harrison P">P Harrison</name>
</author>
<author><name sortKey="Seeman, T" uniqKey="Seeman T">T. Seeman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, M" uniqKey="He M">M He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hillis, Dm" uniqKey="Hillis D">DM Hillis</name>
</author>
<author><name sortKey="Bull, Jj" uniqKey="Bull J">JJ. Bull</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hodcroft, E" uniqKey="Hodcroft E">E. Hodcroft</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holt, Ke" uniqKey="Holt K">KE Holt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huson, Dh" uniqKey="Huson D">DH Huson</name>
</author>
<author><name sortKey="Bryant, D" uniqKey="Bryant D">D. Bryant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacobsen, Kh" uniqKey="Jacobsen K">KH Jacobsen</name>
</author>
<author><name sortKey="Padgett, Jj" uniqKey="Padgett J">JJ. Padgett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Janssens, P" uniqKey="Janssens P">P Janssens</name>
</author>
<author><name sortKey="Pattyn, S" uniqKey="Pattyn S">S Pattyn</name>
</author>
<author><name sortKey="Meyers, W" uniqKey="Meyers W">W Meyers</name>
</author>
<author><name sortKey="Portaels, F" uniqKey="Portaels F">F. Portaels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaser, M" uniqKey="Kaser M">M Kaser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Langmead, B" uniqKey="Langmead B">B Langmead</name>
</author>
<author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL. Salzberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lartillot, N" uniqKey="Lartillot N">N Lartillot</name>
</author>
<author><name sortKey="Philippe, H" uniqKey="Philippe H">H. Philippe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
<author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name>
</author>
<author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA. Suchard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Durbin, R" uniqKey="Durbin R">R. Durbin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Linz, B" uniqKey="Linz B">B Linz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahillon, J" uniqKey="Mahillon J">J Mahillon</name>
</author>
<author><name sortKey="Chandler, M" uniqKey="Chandler M">M. Chandler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marsollier, L" uniqKey="Marsollier L">L Marsollier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marttinen, P" uniqKey="Marttinen P">P Marttinen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merritt, Rw" uniqKey="Merritt R">RW Merritt</name>
</author>
<author><name sortKey="Benbow, Me" uniqKey="Benbow M">ME Benbow</name>
</author>
<author><name sortKey="Small, Plc" uniqKey="Small P">PLC. Small</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyers, Wm" uniqKey="Meyers W">WM Meyers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyers, Wm" uniqKey="Meyers W">WM Meyers</name>
</author>
<author><name sortKey="Shelly, Wm" uniqKey="Shelly W">WM Shelly</name>
</author>
<author><name sortKey="Connor, Dh" uniqKey="Connor D">DH Connor</name>
</author>
<author><name sortKey="Meyers, Ek" uniqKey="Meyers E">EK. Meyers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Monot, M" uniqKey="Monot M">M Monot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moran, Na" uniqKey="Moran N">NA Moran</name>
</author>
<author><name sortKey="Plague, Gr" uniqKey="Plague G">GR. Plague</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mortimer, Td" uniqKey="Mortimer T">TD Mortimer</name>
</author>
<author><name sortKey="Pepperell, Cs" uniqKey="Pepperell C">CS. Pepperell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muelder, K" uniqKey="Muelder K">K Muelder</name>
</author>
<author><name sortKey="Nourou, A" uniqKey="Nourou A">A. Nourou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narh, Ca" uniqKey="Narh C">CA Narh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pakenham, T" uniqKey="Pakenham T">T. Pakenham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pearson, T" uniqKey="Pearson T">T Pearson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Portaels, F" uniqKey="Portaels F">F Portaels</name>
</author>
<author><name sortKey="Elsen, P" uniqKey="Elsen P">P Elsen</name>
</author>
<author><name sortKey="Guimaraes Peres, A" uniqKey="Guimaraes Peres A">A Guimaraes-Peres</name>
</author>
<author><name sortKey="Fonteyne, Pa" uniqKey="Fonteyne P">PA Fonteyne</name>
</author>
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<author><name sortKey="Meyers, Wm" uniqKey="Meyers W">WM. Meyers</name>
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<biblStruct><analytic><author><name sortKey="Stinear, Tp" uniqKey="Stinear T">TP Stinear</name>
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<author><name sortKey="Portaels, F" uniqKey="Portaels F">F Portaels</name>
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<author><name sortKey="Meyers, Wm" uniqKey="Meyers W">WM. Meyers</name>
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</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>Bénin</li>
<li>Cameroun</li>
<li>France</li>
</country>
<region><li>Pays de la Loire</li>
<li>Province d'Anvers</li>
<li>Région flamande</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Angers</li>
<li>Anvers</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université d'Anvers</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Phanzu, Delphin Mavinga" sort="Phanzu, Delphin Mavinga" uniqKey="Phanzu D" first="Delphin Mavinga" last="Phanzu">Delphin Mavinga Phanzu</name>
</noCountry>
<country name="Belgique"><noRegion><name sortKey="Vandelannoote, Koen" sort="Vandelannoote, Koen" uniqKey="Vandelannoote K" first="Koen" last="Vandelannoote">Koen Vandelannoote</name>
</noRegion>
<name sortKey="De Jong, Bouke C" sort="De Jong, Bouke C" uniqKey="De Jong B" first="Bouke C." last="De Jong">Bouke C. De Jong</name>
<name sortKey="Eddyani, Miriam" sort="Eddyani, Miriam" uniqKey="Eddyani M" first="Miriam" last="Eddyani">Miriam Eddyani</name>
<name sortKey="Jordaens, Kurt" sort="Jordaens, Kurt" uniqKey="Jordaens K" first="Kurt" last="Jordaens">Kurt Jordaens</name>
<name sortKey="Jordaens, Kurt" sort="Jordaens, Kurt" uniqKey="Jordaens K" first="Kurt" last="Jordaens">Kurt Jordaens</name>
<name sortKey="Leirs, Herwig" sort="Leirs, Herwig" uniqKey="Leirs H" first="Herwig" last="Leirs">Herwig Leirs</name>
<name sortKey="Meehan, Conor J" sort="Meehan, Conor J" uniqKey="Meehan C" first="Conor J." last="Meehan">Conor J. Meehan</name>
<name sortKey="Portaels, Francoise" sort="Portaels, Francoise" uniqKey="Portaels F" first="Françoise" last="Portaels">Françoise Portaels</name>
<name sortKey="Vandelannoote, Koen" sort="Vandelannoote, Koen" uniqKey="Vandelannoote K" first="Koen" last="Vandelannoote">Koen Vandelannoote</name>
</country>
<country name="Bénin"><noRegion><name sortKey="Affolabi, Dissou" sort="Affolabi, Dissou" uniqKey="Affolabi D" first="Dissou" last="Affolabi">Dissou Affolabi</name>
</noRegion>
<name sortKey="Chauty, Annick" sort="Chauty, Annick" uniqKey="Chauty A" first="Annick" last="Chauty">Annick Chauty</name>
</country>
<country name="Cameroun"><noRegion><name sortKey="Eyangoh, Sara" sort="Eyangoh, Sara" uniqKey="Eyangoh S" first="Sara" last="Eyangoh">Sara Eyangoh</name>
</noRegion>
<name sortKey="Landier, Jordi" sort="Landier, Jordi" uniqKey="Landier J" first="Jordi" last="Landier">Jordi Landier</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Mangas, Kirstie" sort="Mangas, Kirstie" uniqKey="Mangas K" first="Kirstie" last="Mangas">Kirstie Mangas</name>
</region>
<name sortKey="Seemann, Torsten" sort="Seemann, Torsten" uniqKey="Seemann T" first="Torsten" last="Seemann">Torsten Seemann</name>
<name sortKey="Stinear, Timothy P" sort="Stinear, Timothy P" uniqKey="Stinear T" first="Timothy P." last="Stinear">Timothy P. Stinear</name>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Marsollier, Laurent" sort="Marsollier, Laurent" uniqKey="Marsollier L" first="Laurent" last="Marsollier">Laurent Marsollier</name>
</region>
<name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name>
<name sortKey="Landier, Jordi" sort="Landier, Jordi" uniqKey="Landier J" first="Jordi" last="Landier">Jordi Landier</name>
<name sortKey="Marion, Estelle" sort="Marion, Estelle" uniqKey="Marion E" first="Estelle" last="Marion">Estelle Marion</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa

Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa

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	Serveur d'exploration sur les relations entre la France et l'Australie
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